Itachi Uchiha
Itachi Uchiha gained the Mangekyō Sharingan by allegedly killing his best friend, Shisui. With the Mangekyō Sharingan, Itachi was able to use at least three powerful techniques. With his "left Mangekyō" he could use Tsukuyomi, an extremely powerful genjutsu that allowed him to torture opponents for what seemed like days in a matter of seconds.
With his "right Mangekyō" he could use Amaterasu, a ninjutsu which creates virtually-inextinguishable black flames at the user's focal point that continue to burn until the target is reduced to ash. The last of these known techniques was Susanoo, which allowed Itachi to summon a massive ethereal warrior.